Myasthenia gravis immune system

Myasthenia Gravis (MG) - Muscular Dystrophy Association Myasthenia gravis (MG) is a rare autoimmune disease in which the immune system interferes with the transmission of nerve impulses to the muscles. Weakness that gets worse with activity is the main symptom of myasthenia gravis. We have treated such patients by rebooting the immune system with high-dose cyclophosphamide (Hi Cy, 2mgkg which largely eliminates the mature immune system, while leaving hematopoietic precursors intact).

A small but important proportion of patients with myasthenia gravis (MG) are refractory to conventional immunotherapy. Myasthenia gravis - NHS In myasthenia gravis, the immune system damages the communication system between the nerves and muscles, making the muscles weak and easily tired. In people with myasthenia gravis, antibodies bind to nerves and make them unable to stimulate muscles properly.

Myasthenia gravis - NHS

In myasthenia gravis, antibodies (immune proteins produced by the bodys immune system) block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, which prevents the muscle from contracting. Itaposs not clear why this happens, but it has been linked to issues with the thymus gland (a gland in the chest thataposs part of the immune system). The exact mechanisms affected in and around the neuromuscular junction arent yet defined for all types of myasthenia gravis. Myasthenia gravis - Symptoms and causes - Mayo Clinic Dec 1 20Myasthenia gravis is an autoimmune disease, which means the immune system attacks healthy tissue in this case, the neuromuscular junction where nerves and muscles are supposed to communicate.

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