Radioiodine refractory differentiated thyroid cancer

However, local recurrence andor distant metastases occur in approximately of cases during follow-up, and nearly two-thirds of these patients will become RAI-refractory (RR-DTC) with a poor prognosis. Radioiodine (RAI)-refractory thyroid cancer is an uncommon entity, occurring with an estimated incidence of 4-casesyearmillion people. Sep 1 20Background: The management of aggressive and progressing metastatic differentiated thyroid cancer (DTC) is very difficult, and the determination as to when such patients are refractory to 131I therapy (e.g., radioiodine refractory) is problematic and. Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland. Sep 1 20(3)Sylvester Comprehensive Cancer Center, University of Miami - Miller School of Medicine, Miami, FL, USA.

RAI refractoriness is more frequent in older patients, in those with large metastases, in poorly differentiated thyroid cancer, and in those tumors with high 18-fluordeoxyglucose uptake on PETCT.

Radioactive iodine-refractory differentiated thyroid

Most common thyroid cancers are differentiated thyroid cancers (DTCs) and have papillary, follicular, or H rthle cell morphology. Differentiated thyroid cancer (DTC) is usually curable with surgery, radioactive iodine (RAI and thyroid-stimulating hormone (TSH) suppression. Sep 2 20The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective treatment for reducing the risk of recurrence, and even the mortality, of DTC.

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Radioiodine refractory differentiated thyroid cancer

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